Abstract:Background. Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID). The use of this drug family is usually associated with gastric problems. The unique enteric-coated formulas of ibuprofen significantly reduced its side effects which make it relatively safe and most frequently used. Aim. In this study we aimed to outline the impact of ibuprofen on two important metals that are involved in hair growth, zinc (Zn) and iron (Fe). Methods. Twenty male Wistar rats were divided into two equal groups. The first group served as control and treated with saline. The second group was challenged orally with 50 mg/kg ibuprofen daily, for 60 consecutive days. Serum levels of Zn, Fe, ferritin and total iron binding capacity (TIBC) were estimated. Fe and Zn levels in 24 hours urine, liver tissue and stool were determined. Results. Seventy percent of treated rats showed alopecia on both ventral and dorsal sides. Serum levels of Zn, Fe and TIBC were significantly decreased in treated animals. Liver homogenate and 24- hours urine showed marked reduction in Zn contents and significant increase in Fe residues. Concentration of Zn and Fe did not change in stool. Ferritin level was significantly increased in ibuprofen-treated rats. Conclusions. Ibuprofen decreases the availability of both elements for hair growth possibly through extrahepatic utilization of zinc while increasing excretion and tissue retention of iron. It might be advisable to follow Fe and Zn medications with those under long-term ibuprofen treatment especially who suffer hair fall, and have stomach intolerance to other NSAIDs.
Abstract:The effect of high dose of lithium carbonate on rat brain free amino acid kinesis and brain protein content, was studied at different treatment periods. Due to possible use of high doses of anti depressants, as, patients many times do without reference advice, we tried perusal of lithium carbonate high doses (150 mg/kg/d) on four groups of rats, 6/each. They were classified according to duration into, a control group, given saline by same volume and duration (group 1), acute study group, given single dose, left for 2 hours (group 2), sub-acute study group, given a dose each 3 days for 2 weeks(group 3) and a chronic study group, given dose each 3 days for a month(group 4). Brain content of individual free amino acids, ɣ- aminobutyrate (GABA), glycine, tryptophan, aspartate, methionine, tyrosine, phenyl alanine, branched chain amino acids and proline was significantly decreased after 2 hours, 2 weeks and one month of administration. Correspondingly, hydroxyl and dibasic amino acids were increased. This change was accompanied by increased phosphate buffer-insoluble brain protein fraction after two hours of administration, with slow decrease, till nearing normalcy after a month of therapy. This action could be explained as an anabolic effect of lithium on brain protein, which possibly assumes a role of lithium treatment in neuroprotection and neuroregeneration, with a modulatory action on nitrogen balance, activated amidation, hydroxylation and peptidase activation. These pathways, together, possibly published for the first time, elucidating a novel therapeutic potential of lithium in bipolar disorders.
Abstract:Social media is the process where communication and interaction between individuals all over the world takes place. Like all different kinds of technology social media has many advantages but it also has many disadvantages. Saudi Arabia is one of the largest economies and population in the world. The internet users in Saudi Arabia are around 30 million individuals in 2018. This large number of users represents the best choice for market and business not only for legal but also for illegal business-like drug smuggling. In this paper, we try to give some ideas about some drug smuggling cases through social media and the effort of Saudi Arabian Government to control this phenomenon.
Abstract:Introduction\nThis study aimed to epidemiologically examine elderly patients aged ≥65 years who were admitted to the emergency department during a 1-year period due to trauma and fracture detected using radiological imaging.\nMaterials and Methods\nWe enrolled 300 elderly patients admitted to the emergency department of the Medeniyet University Hospital due to trauma between 1 September 2014 and 1 September 2015. We examined patients’ sociodemographic characteristics, radiological images, history of fracture, chronic diseases and drugs used. Finally, attained data were analysed using statistical tests and compared with the relevant literature.\nResults\nOf the 300 patients, 75.7% (n = 227) were females and 24.3% (n = 73) were males. Falls were the leading reason for injuries in this study. As age increased, the number of females, admissions to emergency department and long bone fractures increased (P ˂ 0.05). Furthermore, 62.7% (n = 188) of all patients were discharged and 37.3% (n = 122) were hospitalised to clinics.\nDiscussion\nIn the elderly population using multiple drugs, gender and comorbid diseases are crucial factors related to morbidity and mortality. Thus, family members should be informed about protective measures to decrease multiple drug use as well as to prevent the deterioration of the life comfort of patients and the emergence of possible new cases.
Abstract:The morphological description of the nine most distinctive and rare types of soil infusoria has been given here (Oxytrichaimmemorata Alekperov, 1984, Histriculusmuscorum Kahl, 1932 Urostylagrandis Ehrenberg, 1838 Phialinavermicularis (Müller, 1786), Dyptusfalciformis Kahl 19, Trithigmostomasteini (Blochmann, 1895) , Zosterodasyscantabrica Fernandez-Leborans and Alekperov 1996, Nassulaterricola Foissner 1989, Frontoniadisciformis Alekperov, Obolkina, Wilbert 2012 ). They were found in the SamurYalama National Park located in the Samur Devechi Lowland. The descriptions are made on the basis of an in vivo study and some preparations impregnated with silver.
Abstract:The persistence patterns of the pesticides Malathion, fenitrothion and deltamethrin in fruits of tomato and cucumber were determined. Residues were determined by gas liquid chromatography. Results confirmed that the initial deposit of Malathion and fenitrothion on and in the cucumber, fruits (7.603 and 9.043 µg/g) were higher than on and in tomato fruits (5.390 and7.110 µg/g), respectively. Data also indicated that the initial residue of deltamethrin on and in the tomato fruits (3.660 µg/g) was higher than the initial deposit of deltamethrin on and in the cucumber fruits (3.643 µg/g). The consumable safety time was found to be 10 and 14 days after application on tomato and cucumber. This was found to be enough to reduce the residue below the maximum residue limits (MRL). However, Malathion, fenitrothion and deltamethrin appeared to have relatively longer persistence on cucumber fruits with, t1/2 of 1.98, 2.04 and 1.77 days, than on tomato fruits with, 1.41, 1.41 and 0.4 respectively.
Abstract:For the first time we have conducted molecular-genetic analysis of GALT gene of galactosemia inherited disease in the newborn blood which found at the result of screening conducted maternity houses of Baku city of Azerbaijan Republc. For Azerbaijan people for the first time identification of substitution of adenine nucleotide with guanine nucleotide in GALT gene position 563 was conducted. It leaded to substitution of glycineamino acid with arginine amino acid in position 188 of mutation protein.
Abstract:This research includes the realization of altering the photodegradation activity of titania using composite materials. Three different percentage of doping ZnO with TiO2 were compared. The nanocomposites were synthesized by the sol-gel method. X-ray diffraction (XRD), Field Emission-scanning electron microscopy (FE-SEM), and UV–Vis spectroscopy techniques were used to analyze the prepared samples. XRD results proven the forming of the anatase phase for the TiO2 nanoparticles. The tiny crystallite size and doping with zinc oxide inhibited any phase transformation and promoted the growth of the TiO2 anatase phase. The optical study display that doping another metal oxide lead to an increase in the absorption edge wavelength and a decrease in the energy band gap of titania. Photocatalytic activity of the prepared nanomaterials was successfully tested for photodegradation of methyl blue as a model of water pollutant under sun light. The photocatalytic activity results reveal that the doped nanoparticles offering higher activity than undoped titania.
Abstract:It is defined for each fuzzy set a soft twin fuzzy set and for every fuzzy soft set a\nfuzzy twin set. Studied the binary operations on the soft twin sets, which are generated through the known binary operations on the fuzzy sets. It was applied the generating binary operations on the family of soft twin fuzzy sets to deduce some mathematical structures on them.
Abstract:Masking the color of the cast metal dowel core under an all-ceramic restoration can be a difficult task. A layer of high-performance polymer (BioHPP; Bredent) based on polyether ether ketone (PEEK) was used for coating the metal core as an alternative to the opaque layer of porcelain or composite resin. To address the patient’s chief complain the following treatment plan was chosen: replacing the old zirconia crown and the direct post and core restoration with a cast metal dowel core, coated coronally with BioHPP and an all-ceramic crown. PEEK can be successfully used to cover the metal core if mechanical retention is added and the surface is sandblasted. To improve the adhesive properties of the biopolymer a special conditioner is recommended.